From Scoliosis Wiki

Blood tests for scoliosis is still in its very infant stages. Dr. Alain Moreau and his team in Quebec are the pioneers in this field. They have recently began talking about two types of tests that can be done with regards to idiopathic scoliosis

Functional scoliosis test

The first[ scoliosis blood test] is a functional assay performed with blood cells obtained from 10 ml of blood (equivalent to 2 tea-spoons). As you know, we have previously discovered that many cell types obtained from patients suffering from idiopathic scoliosis (IS) display a differential response in the transmission of melatonin signals. This is possible because melatonin receptors are present in most if not all cell types including blood cells. In other words, the test measures how the cells respond to melatonin. Three distinct responses among IS patients were obtained allowing their classification into three functional subgroups. It should be noted that two distinct methods were performed to determine the functional classification of IS patients, the first using the measurement of cAMP, an intracellular messenger (Moreau et al Spine 2004 & Azeddine et al CORR 2007) and more recently using a more accurate technology called cellular dielectric spectroscopy (Akoume et al Spine 2010), giving both the same functional classification. This functional test has the added advantage of being performed on asymptomatic kids (boys and girls) as well to predict their risks of developing scoliosis. Moreover this functional blood test is also superior because it can be performed without prior knowledge of specifically mutated genes causing IS since we are measuring a function.

Biochemical scoliosis test

The second scoliosis predictive test is a biochemical one where two proteins called Osteopontin (OPN) and soluble CD44 (sCD44) are measured in the blood.